News & Events
Archaea Shape Microbiomes by Using Molecular Spring-Loaded Daggers
In this paper published in Science Advances, the Pilhofer Lab (IMBB) together with the Albers Lab from the University of Freiburg describe the structure and function of contractile injection systems from haloarchaea and show how it can structure the local microbial community they thrive in.
Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia
In a recent publication in Nature Communications, researchers from the Tumor Profiler consortium combined single-cell multi-omics and functional profiling for 21 AML patients to reveal resistance mechanisms to the Bcl-2 inhibitor venetoclax and identify emerging treatment vulnerabilities.
Epigenetic and gene expression novelty in polyploids largely reverts during evolution
A recent study from the Bomblies group (IMPB) in Molecular Biology & Evolution investigates chromatin accessibility and transcriptomic changes upon genome duplication as well as subsequent evolution in Arabidopsis arenosa, showing immediate responses to polyploidy can revert during evolution.
Ribosomal peptides with polycyclic isoprenoid moieties
A recent “Chem” paper by the Piel group (IMB) in collaboration with the Chekan (UNC Greensboro) and Gugger groups (Institut Pasteur) reports a new and unusually complex steroid-like post-translational modification.
The hGID GID4 E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration
A recent "Life Science Alliance" paper by the Peter group (IBC), in collaboration with the Côté (IRCM, Montréal, Canada) and Pertz groups (ICB, Bern), demonstrates a novel role for the human GID E3 ligase in regulating cell migration by targeting the RhoA-GAP ARHGAP11A for proteasomal degradation.