D-BIOL News Channel (EN)

A new study in PLoS Genetics by the Wutz group (IMHS) characterizes the two Ubinuclein genes in mouse development. While mutation of Ubinuclein 1 causes no overt phenotype, Ubinuclein 2 is shown to be critical for embryogenesis with a function in X chromosome inactivation in female embryos advancing our understanding of mammalian dosage compensation.

In a recent "Nature genetics" paper, the Aceto group (IMHS) in collaboration with the Beerenwinkel group (D-BSSE) interrogate clonal heterogeneity in individual circulating tumor cell clusters (CTC clusters), thereby improving our understanding of metastasis-relevant clonal dynamics.

In a recent article in the “Journal of Cell Biology”, the Wieczorek Group reports cryo-EM structures that reveal how the γ-tubulin ring complex (γ-TuRC)-associated protein NEDD1 anchors the complex at microtubule-organizing centers without interfering with microtubule nucleation.

In a “Nature Communications” paper researchers of the Allain lab (IBC) describe an NMR-based approach to characterize molecular condensates without the need to tag or otherwise label the involved molecules. Besides eliminating alteration of results through labels, the method allows the determination of several quantifiable properties at once.

Our lungs rely on alveolar macrophages (AMs) for health. Matsushita & Muri from the Kopf Group (IMHS) published in Cell Reports that AMs need peroxisomes to manage toxic fats, support energy metabolism, mitochondrial fitness, and safeguard lung immunity, highlighting their vital role.