D-BIOL News Channel (EN)
The early bacterium catches the sugar: E. coli outcompetes Salmonella for D-galactose
A recent PLOS Pathogens publication by the Hardt group (IMB) highlights strain-specific nutrient competition between Escherichia coli 8178 and Salmonella Typhimurium for the monosaccharide D-galactose.
How lipid membranes trigger protein aggregation in Parkinson’s—and how to stop it
A new PNAS study by the Michaels group (IBC) uncovers how lipid membranes trigger toxic α-synuclein aggregation and shows how small molecules can inhibit this process.
Cell-guiding microporous hydrogels by photopolymerization-induced phase separation
An innovative method to produce cell-guiding microporous hydrogels has just been published in Nature Communications by the Qin lab at D-HEST in collaboration with the Michaels lab (within the Bringing Materials to Life Consortium).
Ubinuclein 2 is essential for mouse development and functions in X chromosome inactivation
A new study in PLoS Genetics by the Wutz group (IMHS) characterizes the two Ubinuclein genes in mouse development. While mutation of Ubinuclein 1 causes no overt phenotype, Ubinuclein 2 is shown to be critical for embryogenesis with a function in X chromosome inactivation in female embryos advancing our understanding of mammalian dosage compensation.
Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters
In a recent "Nature genetics" paper, the Aceto group (IMHS) in collaboration with the Beerenwinkel group (D-BSSE) interrogate clonal heterogeneity in individual circulating tumor cell clusters (CTC clusters), thereby improving our understanding of metastasis-relevant clonal dynamics.