D-BIOL News Channel (EN)

In a recent article in “The Journal of Cell Biology”, the Wieczorek Group reports cryo-EM structures that reveal how the γ-tubulin ring complex (γ-TuRC)-associated protein NEDD1 anchors the complex at microtubule-organizing centers without interfering with microtubule nucleation.

In a “Nature Communications” paper researchers of the Allain lab (IBC) describe an NMR-based approach to characterize molecular condensates without the need to tag or otherwise label the involved molecules. Besides eliminating alteration of results through labels, the method allows the determination of several quantifiable properties at once.

Our lungs rely on alveolar macrophages (AMs) for health. Matsushita & Muri from the Kopf Group (IMHS) published in Cell Reports that AMs need peroxisomes to manage toxic fats, support energy metabolism, mitochondrial fitness, and safeguard lung immunity, highlighting their vital role.

A recent "PNAS" paper by the Bomblies group (IMPB) demonstrates that key meiotic processes involved in early chromosome pairing, need to be modified to stabilize meiosis (the cell division that creates spores or gametes) in polyploids, which have four instead of two copies of every chromosome.

Recent work by the Peter laboratory (IBC) published in "Molecular Cell", in collaboration with the Pilhofer (IMBB, D-BIOL) and Panse (IMM, UZH) groups, and Toulouse and Geneva collaborators demonstrates that the yeast ribosome hibernation factor Stm1 regulates ribosome homeostasis, balancing degradation and biogenesis in different conditions.