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Quantitative and Qualitative Analysis of Humoral Immunity Reveals Continued and Personalized Evolution in Chronic Viral Infection
During established chronic viral infections, tailored virus-specific antibody responses can promote its eventual control. The extent to which the ensemble of antibodies has to evolve to this end during chronic infection is unclear. A collaborative "Cell Reports" paper by the Oxenius (IMB), Reddy and Stadler (D-BSSE) groups sheds light on the dynamics of antibody responses during acute and chronic viral infections.
Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium
The NLRC4 inflammasome protects from systemic pathogen spread. Annika Hausmann and colleagues from the Hardt lab revealed that intestinal epithelial cells use NLRC4 to control pathogen spread from the gut, while phagocyte NLRC4 was dispensable. This is explained by site-specific regulation of bacterial gene expression.
Darwinian competition between different fetal precursors in tissue resident macrophage development
Tissue-resident macrophages (MΦTR) originate from fetal precursors. The relative potential of fetal precursors in determining development and functional capacity of MΦTR remains unclear. A recent "The EMBO Journal" paper by the Kopf group (IMHS) revealed the underlying molecular mechanism.