Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
The Gstaiger and Aebersold groups (IMSB) present a comprehensive mass-spectrometry-based analysis of human kinase complexes. The work in "Molecular Cell" covers more than 7000 protein interactions for over 300 kinases and suggests new functional associations and disease links for the human kinome.
Protein kinases are essential for signal transduction and control most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite their critical roles in cells and strong association with diseases, good coverage of kinase protein interactions is available for only a fraction of the 535 human kinases.
The Gstaiger and Aebersold teams performed a comprehensive mass-spectrometry-based analysis of human kinase complexes covering more than 300 kinases and over 5,000 previously unreported kinase protein interactions. Computational and functional analysis of the obtained interaction network identified previously described, as well as predict and validate new, kinase functional associations. The presented work uncovered dozens of kinase-disease associations spanning from genetic disorders to complex diseases, including cancer and thus represents a valuable resource for guiding future biomedical studies.
Link to the paper external page "Molecular Cell".