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Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases
The recent eLife paper by the Korkhov group (IMBB, ETHZ & PSI) describes the cryo-EM structure of a Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya, an evolutionary progenitor of the mammalian membrane adenylyl cyclases.
Enhancing precise genome editing efficacy by retargeting undesired outcomes
Genome editing can impart precise modifications to DNA to revert pathogenic mutations or insert novel sequences. However, undesired edits are frequently produced. The Corn group (IMHS) has developed a new approach to increase the abundance of desired outcomes while depleting editing byproducts.