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Distinct N and C Cross-Feeding Networks in a Synthetic Mouse Gut Consortium
A recent “mSystems” paper by the Sauer group (IMSB) unravels with metabolomics the cross-feeding network in a 10 species mouse gut consortium and demonstrates how it is tailored to produce the anti-inflammatory butyrate.
DNA circles promote yeast ageing in part through stimulating the reorganization of Nuclear Pore Complexes
A recent "eLife" paper by the Barral (IBC) and Charvin (IGBMC, Strasbourg) groups demonstrates that age remodels yeast Nuclear Pore Complexes (NPCs), resulting in changes of NPC-associated transport machinery, and dissect the role of extrachromosomal DNA and the SAGA-complex in these changes.
TMED2 restricts SMO trafficking from the ER-Golgi
A recent “PLOS Biology” paper by Di Minin et al. (Wutz group at IMHS) identifies the Golgi protein TMED2 as a novel modulator of the Hedgehog pathway and suggests the ER-Golgi trafficking as a crucial process in the activation of the signalling cascade.