2024
Systematic identification of structure-specific protein–protein interactions
A paper from the Picotti group (IMSB, in collaboration with the Beltrao, Riek and Korkhov groups) describes a method to screen for conformation-specific protein-protein interactions and pinpoint interaction sites. They used it to study interactors of the monomeric and amyloid states of alpha-synuclein.
Julia Vorholt elected International Member of the National Academy of Sciences
The National Academy of Sciences recently announced the election of new members and international members. One of the awardees is Julia Vorholt, Professor of Microbial Physiology at the D-BIOL's Institute of Microbiology.
Inhibition mechanism of human oligosaccharyltransferase OST-A by the drug NGI-1
A recent article in the journal "Cell" by the Locher group (IMBB) in collaboration with Kaelin (Dana-Farber Cancer Institute) and Contessa (Yale School of Medicine) groups revealed how the human OST-A enzyme is inhibited by the drug NGI-1.
Exploring Salmonella-host cell interactions from inside out
In a recent PLOS Biology article, the Vorholt group (IMB) together with the Hardt (IMB) and Sellin (Uppsala University) labs report the direct placement of the bacterial pathogen Salmonella into the cytosol of enteroid cells, enabling spatiotemporal analysis of host-pathogen interactions.
Transport of CLCA2 to the nucleus by extracellular vesicles controls keratinocyte survival and migration
A recent "Journal of Extracellular Vesicles" paper by the Werner group (IMHS) identified an unexpected nuclear transport mechanism of the stress-regulated transmembrane protein CLCA2 by extracellular vesicles (EVs). The presence of CLCA2 in the nucleus is required for the regulation of key cellular functions in skin keratinocytes.