2024
The scramblases VMP1 and TMEM41B are required for primitive endoderm specification by targeting WNT signaling
A recent Cell Death and Differentiation paper by the Di Minin and Wutz groups (IMHS), in collaboration with the Weis (IBC) group, reveals how ER-resident scramblases VMP1 and TMEM41B regulate the trafficking of the WNT pathway receptor FZD2, shedding light on stem cell differentiation.
FGF receptor kinase inhibitors exhibit broad antiviral activity by targeting Src family kinases
A recent "Cellular and Molecular Life Sciences" paper by the Werner group (IMHS) identifies broad-spectrum antiviral activities of FGF receptor kinase inhibitors, which involve their unexpected effect on Lyn kinase. These data suggest Lyn as a promising target for the treatment of viral infections.
Leaf microbiota shaped by dose-dependent general non-self response genes
Adaptation to biotic and abiotic stress is crucial for the health of living organisms. In an article published in Nature Plants, Keppler et al. describe how the commensal microbiota triggers plant immune responses that feed back to tune microbial colonization of plants.
Archaea Shape Microbiomes by Using Molecular Spring-Loaded Daggers
In this paper published in Science Advances, the Pilhofer Lab (IMBB) together with the Albers Lab from the University of Freiburg describe the structure and function of contractile injection systems from haloarchaea and show how it can structure the local microbial community they thrive in.
Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia
In a recent publication in Nature Communications, researchers from the Tumor Profiler consortium combined single-cell multi-omics and functional profiling for 21 AML patients to reveal resistance mechanisms to the Bcl-2 inhibitor venetoclax and identify emerging treatment vulnerabilities.