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In vivo PAR-CLIP (viP-CLIP) of liver TIAL1 unveils targets regulating cholesterol synthesis and secretion
A recent "Nature Communications" paper by the Stoffel group (IMHS) in collaboration with the Tuschl and Chao labs reports the development of viP-CLIP, a method capable of identifying RBP networks in tissues, and the identification a novel factor implicated in regulation of cholesterol biosynthesis.
Engineering of the Endogenous HBD promoter increases HbA2
Recently published eLife paper by the Corn group (IMHS) demonstrates that using CRISPR-Cas9 gene-editing to insert transcription factor binding sites can increase transcriptional activity and expression of Hemoglobin A2.
Resistance to mesenchymal reprogramming sustains metastatic propagation in breast cancer
A recent "Cell Reports" paper authored by Massimo Saini from the group of Nicola Aceto (IMHS) in collaboration with the DKFZ Heidelberg and the Helmholtz Centre Munich delivers an unexpected paradigm shift in the role of Epithelial-Mesenchymal Transition (EMT) in metastatic breast cancer.