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Integrated drug response profiling of myelofibrosis patients
A recent Nature Communications paper by the Snijder (IMSB) and Wollscheid (ITM) groups in collaboration with the Theocharides (USZ), Lopes (UZH), and Skoda (USB) groups, describes drugs targeting cancerous stem cells in blood of myelofibrosis patients and molecular mechanisms driving these drug responses.
Genomic footprinting uncovers global transcription factor responses to amino acids in E. coli
A "Cell Systems" paper by the Sauer lab (IMSB) used a recent bacterial genomic footprinting approach to globally map the transcriptional response of E. coli to four amino acids, revealing much broader regulatory responses than anticipated, with about 682 novel transcription factor-DNA interactions.
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5
An "EMBO Molecular Medicine" paper by the Werner group (IMHS) shows that the NRF3 protein is downregulated or even absent in invasively growing cancer cells of patients with epithelial skin cancer, resulting in enhanced malignancy due to the upregulation of the unfolded protein response regulator HSPA5.