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Partial closure of the gamma-tubulin ring complex by CDK5RAP2 activates microtubule nucleation
A recent “Developmental Cell” paper by the Wieczorek group (IMBB) reports a novel structure of the mammalian gamma-tubulin ring complex and demonstrates how the centrosomal protein CDK5RAP2 stimulates its microtubule-nucleating activity at sites of microtubule assembly.