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Archaea Shape Microbiomes by Using Molecular Spring-Loaded Daggers
In this paper published in Science Advances, the Pilhofer Lab (IMBB) together with the Albers Lab from the University of Freiburg describe the structure and function of contractile injection systems from haloarchaea and show how it can structure the local microbial community they thrive in.
Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia
In a recent publication in Nature Communications, researchers from the Tumor Profiler consortium combined single-cell multi-omics and functional profiling for 21 AML patients to reveal resistance mechanisms to the Bcl-2 inhibitor venetoclax and identify emerging treatment vulnerabilities.