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Architecture and composition of the human pyruvate dehydrogenase complex elucidated
In a recent "Science Advances" paper, the Glockshuber group (IMBB), together with the cryo-EM hub, the Zenobi group (D-CHAB) and Alexander Leitner (IMSB) solved the long-standing conundrum of the precise subunit composition and core architecture of the mammalian pyruvate dehydrogenase complex.
An evolutionarily conserved mechanism controls reversible amyloids via pH-sensing regions
A recent “Developmental Cell” paper by the Peter group (IBC), in collaboration with the Riek, Arosio, Mezzenga (ETH), and Knowles (Cambridge) groups, reveals an evolutionarily conserved mechanism that regulates amyloid formation and disassembly, profoundly affecting cellular metabolism and growth.
Pedro Beltrao elected EMBO member
EMBO is an organization of leading researchers that promotes excellence in the life sciences in Europe and beyond. Today it announced the election of 120 researchers, one of which is Pedro Beltrao, group leader at the Institute of Molecular Systems Biology (Department of Biology, ETHZ). Through this lifelong honour, new EMBO Members and Associate Members are recognized for their outstanding achievements in the life sciences.
CCAR1 promotes DNA repair via alternative splicing
A recent "Molecular Cell" paper by the Corn group (IMHS) in collaboration with the Jonas (IMBB) and Zavolan (University of Basel) groups demonstrates a novel role of CCAR1 in DNA repair
FilamentID reveals the composition and function of metabolic enzyme polymers
A recent "Cell" paper by the Pilhofer Lab (IMBB) and the Matos Lab (formerly IBC, now Max Perutz Labs in Vienna) unveils a multiscale filament identification workflow to characterize protein filaments that assemble during the developmental program of gamete formation in budding yeast.