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Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters

In a recent "Nature genetics" paper, the Aceto group (IMHS) in collaboration with the Beerenwinkel group (D-BSSE) interrogate clonal heterogeneity in individual circulating tumor cell clusters (CTC clusters), thereby improving our understanding of metastasis-relevant clonal dynamics.
Structure of the microtubule-anchoring factor NEDD1 bound to the γ-tubulin ring complex

In a recent article in the “Journal of Cell Biology”, the Wieczorek Group reports cryo-EM structures that reveal how the γ-tubulin ring complex (γ-TuRC)-associated protein NEDD1 anchors the complex at microtubule-organizing centers without interfering with microtubule nucleation.
Label-free Characterization of Liquid-Liquid Phase Separation

In a “Nature Communications” paper researchers of the Allain lab (IBC) describe an NMR-based approach to characterize molecular condensates without the need to tag or otherwise label the involved molecules. Besides eliminating alteration of results through labels, the method allows the determination of several quantifiable properties at once.
Peroxisomes are critical for a unique metabolic demand and survival of alveolar macrophages

Our lungs rely on alveolar macrophages (AMs) for health. Matsushita & Muri from the Kopf Group (IMHS) published in Cell Reports that AMs need peroxisomes to manage toxic fats, support energy metabolism, mitochondrial fitness, and safeguard lung immunity, highlighting their vital role.
Improved synapsis promotes meiotic stability in genome duplicated Arabidopsis arenosa

A recent "PNAS" paper by the Bomblies group (IMPB) demonstrates that key meiotic processes involved in early chromosome pairing, need to be modified to stabilize meiosis (the cell division that creates spores or gametes) in polyploids, which have four instead of two copies of every chromosome.