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Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels
The recent "Science Advances" paper by the group of Volodymyr Korkhov (IMBB, ETHZ & PSI) in collaboration with the Bortolozzi (UniPD) and Picotti (IMSB) groups describes the structures of Cx32 gap junction channel and hemichannel, providing clues to the molecular defect in CMT1X disease-associated mutant Cx32 hemichannels.
Serine protease 35 regulates the fibroblast matrisome in response to hyperosmotic stress
A "Science Advances" paper by the Werner group (IMHS) shows how fibroblasts in culture and in wounded skin respond to hyperosmotic stress by upregulation of serine proteinase 35, which regulates the matrisome and thereby affects cell proliferation.
ATP-independent substrate recruitment to proteasomal degradation in mycobacteria
A recent "Life Science Alliance " paper by the Weber-Ban group (IMBB) in collaboration with the Picotti group (IMSB) demonstrates the key determinants for substrate selection for ATP-independent proteasomal degradation, which include but are not limited to partial disorder.
Structures of connexin-43 gap junction channel and hemichannel in a putative closed state
The recent eLife paper by the group of Volodymyr Korkhov (IMBB, ETHZ & PSI), in collaboration with the Gervasio (UniGe), Bortolozzi (UniPD), Picotti (IMSB, ETHZ) and Zamboni (IMSB, ETHZ) groups describes the structures of connexin-43 gap junction channel and hemichannel in a putative closed state.
Luminal neutrophils block pathogen attacks to help intestinal epithelium better fight Salmonella infections
Neutrophils enter the gut lumen during gut infections, but their exact function is still an enigma. A recent "PloS Pathogens" paper by the Hardt group (IMB) sheds light on this and reveals that Salmonella induced diarrhea, neutrophils form a physical barrier in front of the gut epithelium and reduce pathogen attack from the luminal side.