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Julia Vorholt, Professor at the Institute of Microbiology, Department of Biology, has been awarded the Feodor Lynen Medal 2024 for her work in the field of biochemistry.  Congratulations!

Deep Interactome Profiling (DIP-MS) offers a sensitive and comprehensive method to study protein complex isoforms concurrently present in affinity purifications. The method combines protein fractionation profiling with machine learning to study modular protein organisation at a high level of detail. The implemented method was developed in the Gstaiger and Aebersold lab (all IMSB) and has been recently published in “Nature Methods”.

A recent article in the journal “Nature Communications” by the Locher group (IMBB) in collaboration with the Kossiakoff group (The University of Chicago), the Urban group (Heidelberg University), the Glebe group (Justus Liebig University Giessen), and the Geyer group (Justus Liebig University Giessen) describes the structural basis of mimicked HBV/HDV viral peptide drug interaction with its receptor NTCP.

In a "Nature Chemical Biology" paper, the Allain lab (IBC) and collaborators including the Michaels group (IBC) mechanistically describe how droplets of the protein fused in sarcoma (FUS) mature. They grow over time a hard shell, which plays a critical role in droplet function.

To study the dynamics of microbiome assembly with strain-level resolution, the Vorholt, Hardt, and Sunagawa labs (all IMB) jointly developed a novel genomic barcoding system, the WISH-tags. These were used to assess how the order of arrival order impacts colonization in plant and mammalian microbiomes.