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Modular microfluidics enables kinetic insight from time-resolved cryo-EM

In a recent "Nature Communications" article, the Peter group (IBC) reports a modular microfluidic method allowing time-resolved cryo EM sample preparation to visualize biochemical reaction intermediates on sub-second timescales for kinetic and structural characterization.

29.07.2020

Antagonism of interferon signaling by fibroblast growth factors promotes viral replication

Graphical abstract Werner paper

A recent "EMBO Molecular Medicine" paper by the Werner group (IMHS) in collaboration with the Oxenius group (IMB) demonstrates a novel role of FGFs in the control of viral replication and suggests the use of FGF receptor antagonists for the treatment of viral infections.

28.07.2020

Structural insights into the mechanism of mitoribosomal large subunit biogenesis

Structures of two unique mitoribosomal large subunit assembly intermediates, 28 identified assembly factors, supportive biochemical RNAi knockdowns and more was reported in a recent "Molecular Cell" publication as a result of a fruitful collaboration between the Schneider group at the University of Berne and the Ban lab at ETH Zurich.

22.07.2020

New module of transcriptional regulator Integrator links its cleavage subunit and RNA/DNA

Integrator is an essential transcription regulator and RNA processing machinery. It cuts RNA to form the 3'-ends of non-coding RNAs and to terminate production of some mRNAs. Work from the Jonas lab published in "Nature Communications" characterizes the role of a new Integrator module in both processes.

21.07.2020

Multi-layered proteomics for the characterization of cancer mutations

Genomic mutations are associated with a variety of human diseases but their effect on cellular networks remain incompletely understood. A recent “Nature Communications” paper by the Aebersold group shows how cancer-associated genomic mutations modulate the cellular proteome and are translated into molecular phenotypes.

21.07.2020

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Department of Biology
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