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Identification of a key regulator of bile acid production and liver regeneration
A "Science Signaling" paper by the Werner group (IMHS) describes an essential function of the ubiquitin ligase Uhrf2 in liver regeneration. Loss of Uhrf2 in hepatocytes increased the production of cholesterol, resulting in the accumulation of toxic bile acids that caused liver failure after partial hepatectomy.
Distribution and diversity of 'Tectomicrobia', a deep-branching uncultivated bacterial lineage harboring rich producers of bioactive metabolites
In a recent ISME Communications paper, the Piel group (Institute of Microbiology) in collaboration with the Sipkema, Crews, Vickneswaran and Cárdenas groups, describe the distribution and diversity of a new candidate phylum ‘Tectomicrobia’.
Inhoffen Medal 2023 awarded to Prof. Jörn Piel
The Inhoffen Medal is one of the most prestigious German prizes within the area of natural product research. The Inhoffen lecture and the award ceremony take place since 1994.
Modular Oxime Formation by a trans-AT Polyketide Synthase
In a recent Angewandte Chemie paper, the Piel group (IMB) in collaboration with the Biomolecular NMR Spectroscopy Platform, and the Université de Lorraine showed that a trans-AT polyketide synthase installs methylated oximes into benzolactone enamides in a modular fashion.
Metabolomics identifies the intestinal geography of microbial metabolite production
A recent "Nature Metabolism" paper by the Sauer (IMSB) and Macpherson groups (Inselspital Bern) disentangled the origin of metabolites in different intestinal niches through comparative metabolomic analyses of the gut of healthy colonized versus germ-free mice.