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06

KappaBle mice: illuminating NF-kB

A recent "Mucosal Immunology" paper by the Kopf group (IMHS) describes the generation of KappaBle fluorescent reporter animals that allow sensitive, low background, high-throughput detection of the activity of transcription factor NF-kB in all cell types.

22.06.2022

Mre11-Rad50 oligomerization promotes DNA double-strand break repair

Kissling paper Nature Communications May 2022

A recent “Nature Communications” paper by the Peter and Cejka groups (IBC, ETH/IRB) reveals how the oligomerization of a conserved protein complex is critical for DNA damage signaling, DNA repair and telomere maintenance, with potential implications for cancer predisposition and chemoresistance.

10.06.2022

METALIC reveals interorganelle lipid flux in live cells by enzymatic mass tagging

Graphical abstract Peter paper Nature Cell Biology May 2022

A recent study in "Nature Cell Biology" by the Peter group (IBC) and the former Kornmann group (now at the University of Oxford), demonstrates a new versatile strategy to track the movement of lipids between organelles in vivo, using a combination of enzyme-based chemical modification and mass spectrometry.

07.06.2022

AI-driven discovery of novel chemical structures by mass spectrometry

Graphical abstract Zamboni paper Nature Methods June 2022

The Zamboni group presents a generally applicable method that enables de novo generation of chemical structures directly from mass spectrometry data. The work was done in collaboration with the group of Prof. Böcker in Jena and was recently published in Nature Methods.

02.06.2022

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Department of Biology
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